苯妥英钠可增加大鼠对65锌的吸收。
Phenytoin increases 65zinc absorption in the rat.
作者信息
Weismann K, Knudsen L, Høyer H
出版信息
J Invest Dermatol. 1978 Dec;71(6):396-7. doi: 10.1111/1523-1747.ep12556887.
PMID:722118
Abstract
A single oral dose of 65Zn was given to groups of rats, 6 or 7 in each, which were started on phenytoin. The drug was given in daily doses of 10, 50, and 100 mg for 10 days. The retention of 65Zn was followed by a whole body counter, and the net absorption of 65Zn was calculated. All phenytoin doses studied were found to increase zinc absorption significantly.
摘要
给每组6或7只开始服用苯妥英钠的大鼠口服单剂量的65锌。药物以每日10毫克、50毫克和100毫克的剂量服用10天。用全身计数器跟踪65锌的潴留情况，并计算65锌的净吸收量。研究发现，所有研究的苯妥英钠剂量均显著增加锌的吸收。
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