Trounson A O, Leeton J F, Wood C, Webb J, Wood J
Science. 1981 May 8;212(4495):681-2. doi: 10.1126/science.7221557.
Normal pregnancies have been established in four women with tubal infertility by fertilization in vitro, embryo culture, and embryo transfer after stimulation of follicular growth with clomiphene citrate. In three of these women the time of oocyte maturation was controlled by human chorionic gonadotropin. This procedure for the control of ovulatory response has many advantages when compared with the previously successful method of using the natural ovulatory cycle.
通过体外受精、胚胎培养以及用枸橼酸氯米芬刺激卵泡生长后进行胚胎移植，四位输卵管性不孕的女性成功实现了正常妊娠。其中三位女性的卵母细胞成熟时间由人绒毛膜促性腺激素控制。与之前成功使用的自然排卵周期方法相比，这种控制排卵反应的方法有许多优点。
