Putrali J, Dazo B C, Hardjawidjaja L, Sudomo M, Barodji A
Southeast Asian J Trop Med Public Health. 1980 Dec;11(4):480-6.
This pilot control project was an intervention study, consisting of: 1) treating the positive cases with Niridazole; 2) spraying the foci with Niclosamide; 3) improving the water supply system and construction of public latrines. The intervention not only has lowered the human prevalence rate, but has also lowered the transmission of the disease in that area. Niridazole appeared relatively safe and effective, the cure rate after one year was 80%. Spraying the foci with Niclosamide 20-40 mg per litre did not appear very effective. Using this epidemiological data it was estimated that infected persons would become spontaneously negative after 4.75 years, if there was no reinfection.
这个试点控制项目是一项干预性研究，包括：1）用硝唑咪治疗阳性病例；2）用氯硝柳胺喷洒疫源地；3）改善供水系统并建造公共厕所。该干预措施不仅降低了人群患病率，还降低了该地区疾病的传播。硝唑咪似乎相对安全有效，一年后的治愈率为80%。用每升20 - 40毫克的氯硝柳胺喷洒疫源地效果似乎不太明显。根据这些流行病学数据估计，如果没有再次感染，感染者将在4.75年后自然转阴。
