Steinhagen W H, Cavender F L, Cockrell B Y
J Environ Pathol Toxicol. 1978 Jan-Feb;1(3):267-77.
Groups of rats and guinea pigs were exposed, by inhalation, to 0.25, 2.5, and 25 mg/m3 of aluminum chlorhydrate (ACH) for six months to study the effects of a common component of antiperspirants. Similar groups of animals of both species exposed to clean air served as controls. The ACH was generated as a particulate dust using a Wright dust feed mechanism. After six months of exposure, animals were sacrificed. Decreases in body weight were seen in rats exposed to 25 mg/m3 of ACH. Marked increases in lung weights and significant increases in lung to body weight ratios were seen in rats and guinea pigs exposed to 25 mg/m3 of ACH. The lungs of all rats and guinea pigs showed significant dose-related increases in aluminum accumulation when exposed to either 0.25, 2.5, or 25 mg/m3 of ACH. The lungs of all rats and guinea pigs exposed to either 2.5 or 25 mg/m3 of ACH contained exposure-related granulomatous reactions characterized by giant vacuoled macrophages containing basophilic material in association with eosinophilic cellular debris.
将大鼠和豚鼠分组，通过吸入方式使其暴露于浓度为0.25、2.5和25毫克/立方米的碱式氯化铝（ACH）环境中六个月，以研究止汗剂常见成分的影响。将暴露于清洁空气中的两组相同物种动物作为对照。使用赖特粉尘进料机制将ACH生成颗粒粉尘。暴露六个月后，处死动物。暴露于25毫克/立方米ACH的大鼠体重下降。暴露于25毫克/立方米ACH的大鼠和豚鼠肺重量显著增加，肺与体重之比也显著增加。当暴露于0.25、2.5或25毫克/立方米的ACH时，所有大鼠和豚鼠的肺中铝积累量均呈现显著的剂量相关性增加。暴露于2.5或25毫克/立方米ACH的所有大鼠和豚鼠的肺中均含有与暴露相关的肉芽肿反应，其特征为含有嗜碱性物质的巨大空泡巨噬细胞与嗜酸性细胞碎片相关联。
