Agrawal A K, Squibb R E
Toxicol Lett. 1981 Jan;7(3):233-8. doi: 10.1016/0378-4274(81)90074-6.
Acrylamide (20 mg/kg) was administered by gavage to time-pregnant Fischer 344 rats daily from day 7 to day 16 of gestation. Acrylamide did not affect the number, size, or body weights of litters obtained but did decrease the [3H]spiroperidol binding in striatal membranes of 2-week-old pups. This effect could not be seen at 3 weeks of age. Scatchard analysis showed that acrylamide changed the affinity as well as the number of dopamine receptor sites. There were no signs of maternal toxicity in dosed mothers as evaluated by their body weights or general appearance.
在妊娠第7天至第16天期间，每天给怀孕的Fischer 344大鼠经口灌胃给予丙烯酰胺（20毫克/千克）。丙烯酰胺不影响产仔数、仔鼠大小或体重，但确实降低了2周龄幼鼠纹状体膜中[3H]螺哌啶的结合。在3周龄时未观察到这种效应。Scatchard分析表明，丙烯酰胺改变了多巴胺受体位点的亲和力和数量。通过体重或总体外观评估，给药母鼠没有母体毒性的迹象。
