Häkkinen I P, Heinonen R, Inberg M V, Viikari S J
Acta Chir Scand. 1980;146(7):507-10.
Discrimination between histologically confirmed benign and malignant gastric ulcerations was studied, using an oncofetal antigen (FSA) as the parameter of malignant transformation. In chronic gastric ulcer FSA could be found in 54.2% as compared with 20.0% in duodenal ulcer patients. 91.1% of gastric cancers were FSA positive. A current epidemiological study on a non-selected population gives 8.8% FSA secretors. The study supports the earlier conception that chronic gastric ulcer must be considered a precursor of cancer, and indicates the need, especially in cases showing FSA secretion, for active surgical therapy or a long-term follow-up with endoscopic biopsies.
利用一种癌胚抗原（FSA）作为恶性转化的参数，对经组织学证实的良性和恶性胃溃疡进行了鉴别研究。在慢性胃溃疡患者中，54.2%可检测到FSA，而十二指肠溃疡患者中这一比例为20.0%。91.1%的胃癌患者FSA呈阳性。一项针对非特定人群的当前流行病学研究显示，FSA分泌者占8.8%。该研究支持了早期的观点，即慢性胃溃疡必须被视为癌症的先兆，并表明尤其对于那些显示FSA分泌的病例，需要积极的手术治疗或通过内镜活检进行长期随访。
