Halse J, Melsen F, Mosekilde L
Acta Endocrinol (Copenh). 1981 May;97(1):18-22. doi: 10.1530/acta.0.0970018.
Iliac crest bone biopsies from 18 patients with active acromegaly, of whom 11 had received tetracycline double-labelling, were evaluated by quantitative histomorphometry and compared with age- and sex-matched normal controls. A significant increase (P less than 0.01) was found in both cortical (175%) and trabecular (130%) bone mass. In trabecular bone, resorption surfaces and active (tetracycline-labelled) and total formation surfaces were increased (P less than 0.05 and P less than 0.01, respectively) causing an enhanced bone turn-over at tissue level (P less than 0.01). The increased trabecular bone mass indicates a positive net balance per remodelling cycle and, therefore, larger than normal bone remodelling units, which in part may explain the increased bone turn-over at tissue level. The activity of the osteoblasts active in mineralization (the appositional rate) was increased (P less than 0.01) and positively related to the fasting serum growth hormone levels (Rs = 0.69, P less than 0.05). The average activity of active and inactive osteoblasts (bone formation rate at basic metabolic unit (BMU) level) was insignificantly increased. The proportion of active (tetracycline labelled) to nonactive formation surfaces was normal. The bone changes were unrelated to serum levels and urinary excretions of calcium and phosphorus or to renal excretion of total and non-dialyzable hydroxyproline or cAMP.
对18例活动性肢端肥大症患者的髂嵴骨活检标本进行了评估，其中11例接受了四环素双标记，采用定量组织形态计量学方法，并与年龄和性别匹配的正常对照进行比较。发现皮质骨（175%）和小梁骨（130%）骨量均显著增加（P<0.01）。在小梁骨中，吸收表面、活跃（四环素标记）和总形成表面均增加（分别为P<0.05和P<0.01），导致组织水平的骨转换增强（P<0.01）。小梁骨量增加表明每个重塑周期的净平衡为正，因此，骨重塑单位大于正常，这在一定程度上可以解释组织水平骨转换增加的原因。参与矿化的成骨细胞活性（沉积速率）增加（P<0.01），且与空腹血清生长激素水平呈正相关（Rs=0.69，P<0.05）。活跃和不活跃成骨细胞的平均活性（基本代谢单位（BMU）水平的骨形成速率）略有增加。活跃（四环素标记）与非活跃形成表面的比例正常。骨变化与血清钙、磷水平及尿排泄量，或与总羟脯氨酸和非透析性羟脯氨酸或环磷酸腺苷的肾排泄量无关。
