Claesson-Backlund H
Acta Pharmacol Toxicol (Copenh). 1981 Jan;48(1):21-5. doi: 10.1111/j.1600-0773.1981.tb01582.x.
Pigmented rats were kept under different light/darkness patterns for 5-12 days. The response of the iris sphincter in enucleated eyes was tested with pilocarpine as a standard stimulus. The eyes were either decorneated or intact. The maximum response (no subsensitivity) was obtained after continuous darkness and the minimum (maximum subsensitivity) after continuous light. Six hours of light and one block of 18 hours of darkness per day caused distinct subsensitivity, but less than if the light was interrupted by six 3-hour darkness periods. Further subdivision of the light into twelve 30-min. periods made no difference. One 18-hour block of light followed by 6 hours of darkness caused less subsensitivity than continuous light. Subdividing the darkness into six 1-hour periods made no significant difference.
将有色大鼠置于不同的光照/黑暗模式下5至12天。以毛果芸香碱作为标准刺激物，测试摘除眼球的虹膜括约肌的反应。眼睛要么去除角膜，要么保持完整。连续黑暗后获得最大反应（无敏感性降低），连续光照后获得最小反应（最大敏感性降低）。每天6小时光照和1个18小时黑暗时段会导致明显的敏感性降低，但比光照被6个3小时黑暗时段打断时要小。将光照进一步细分为12个30分钟时段没有差异。1个18小时光照时段后接着6小时黑暗，导致的敏感性降低比连续光照要小。将黑暗细分为6个1小时时段没有显著差异。
