Laidler P, Kay J M
J Pathol. 1978 Jan;124(1):27-33. doi: 10.1002/path.1711240107.
We studied the ultrastructure of the carotid body of three normal rats and three rats living in a hypobaric chamber at a pressure of 460 mm Hg for 27, 28 and 35 days respectively. The type I cells of the carotid bodies of our hypoxic rats were enlarged due to an increase in the volume of their cytoplasm. Many of their dense core vesicles were vacuolated and the core was displaced eccentrically to become adherent to the limiting membrane of the vesicle. The concentration and distribution of dense core vesicles remained unaltered and there were no obvious changes in the mitochondria, ribosomes or Golgi apparatus. There was pronounced capillary dilatation in the carotid bodies of all three rats exposed to chronic hypoxia. This change was accompanied by attenuation of capillary endothelial cells and increased frequency of endothelial fenestrations. There were no structural changes in the type II cells.
我们研究了三只正常大鼠以及分别在460毫米汞柱压力的低压舱中生活27天、28天和35天的三只大鼠的颈动脉体超微结构。我们的低氧大鼠颈动脉体的I型细胞因细胞质体积增加而增大。它们许多致密核心囊泡出现空泡化，核心偏心移位并附着于囊泡的界膜。致密核心囊泡的浓度和分布保持不变，线粒体、核糖体或高尔基体没有明显变化。所有三只暴露于慢性低氧的大鼠的颈动脉体均出现明显的毛细血管扩张。这种变化伴随着毛细血管内皮细胞变薄和内皮窗孔频率增加。II型细胞没有结构变化。
