Laidler P, Kay J M
J Pathol. 1975 Nov;117(3):183-91. doi: 10.1002/path.1711170308.
A quantitative histological study was carried out on the carotid bodies of 10 normal rats and 10 rats living in a hypobaric chamber at a pressure of 460 mm Hg from 25 to 96 days. In the chronically hypoxic rats there was a four-fold increase in the mean combined volume of the carotid bodies. Morphometric analysis disclosed a three-fold increase in the mean volume of specialised glomic cells and a ten-fold increase in the mean volume of capillaries, although the proportion of glomic cells was actually significantly decreased. In all our hypoxic rats there was evidence of both right and left ventricular hypertrophy. However, there was no linear relation between total carotid body volume or volume of glomic cells on one hand and the right and left ventricular weight, on the other hand. Although there was no linear relation between combined total carotid body volume and duration of hypoxia, the linear relation between glomic cell volume and duration of hypoxia was significant at the 5 per cent. level. The increase in vascularity of the hypoxic carotid body may be a mechanism to increase blood flow and thus oxygen transport to a hypoxic organ with increased metabolic activity. Small quantities of an amorphous hyaline material of unknown nature were found in relation to capillaries and type I cells in all the hypoxic rats.
对10只正常大鼠和10只在460毫米汞柱压力的低压舱中生活25至96天的大鼠的颈动脉体进行了定量组织学研究。在慢性缺氧大鼠中，颈动脉体的平均总体积增加了四倍。形态计量分析显示，特化的球细胞平均体积增加了三倍，毛细血管平均体积增加了十倍，尽管球细胞的比例实际上显著降低。在我们所有的缺氧大鼠中，都有左右心室肥大的证据。然而，一方面颈动脉体总体积或球细胞体积与另一方面左右心室重量之间没有线性关系。虽然颈动脉体总体积与缺氧持续时间之间没有线性关系，但球细胞体积与缺氧持续时间之间的线性关系在5%水平上具有显著性。缺氧颈动脉体血管增多可能是一种增加血流量从而将氧气输送到代谢活动增强的缺氧器官的机制。在所有缺氧大鼠中，在毛细血管和I型细胞中发现了少量性质不明的无定形透明物质。
