Vahouny G V, Connor W E, Roy T, Lin D S, Gallo L L
Am J Clin Nutr. 1981 Apr;34(4):507-13. doi: 10.1093/ajcn/34.4.507.
Studies have been conducted on the absorbability of individual sterols from a mixture of oyster sterols when administered intragastrically to rats with indwelling catheters in the left thoracic duct. In addition, the effect of oyster sterols on cholesterol absorption has been assessed using [4-14C] cholesterol in the mixture, and comparison against absorption of cholesterol alone. The order of absorbability (percentage absorption) of individual sterols from the mixture of oyster sterols was: cholesterol greater than or equal to 26-carbon sterols greater than or equal to dehydrocholesterol greater than 24-methylene cholesterol greater than brassicasterol greater than plant sterols. The absorption of noncholesterol sterols was 8.2 +/- 0.8% of the fed dose, or less than half of that for an equivalent level of cholesterol alone. The presence of these sterols in mixtures containing cholesterol reduced lymphatic absorption of cholesterol by 25 to 40% compared to absorption of the same amount of cholesterol administered alone, or to an amount of cholesterol equal to the total oyster sterols, respectively. These studies suggest that shellfish sterols are poorly absorbed, and, like plant sterols, effectively reduce dietary and/or endogenous cholesterol absorption from the intestine.
在将牡蛎甾醇混合物经胃内给予左胸导管留置导管的大鼠后，对其中各甾醇的吸收情况进行了研究。此外，利用混合物中[4-¹⁴C]胆固醇评估了牡蛎甾醇对胆固醇吸收的影响，并与单独胆固醇的吸收情况进行了比较。牡蛎甾醇混合物中各甾醇的吸收能力顺序（吸收百分比）为：胆固醇≥26碳甾醇≥脱氢胆固醇＞24-亚甲基胆固醇＞油菜甾醇＞植物甾醇。非胆固醇甾醇的吸收量为喂食剂量的8.2±0.8%，或低于同等水平单独胆固醇吸收量的一半。与单独给予相同量胆固醇或与等于总牡蛎甾醇量的胆固醇相比，含胆固醇混合物中这些甾醇的存在使胆固醇的淋巴吸收减少了25%至40%。这些研究表明，贝类甾醇吸收不良，并且与植物甾醇一样，能有效减少肠道对膳食和/或内源性胆固醇的吸收。
