Crawford C L, Hardwicke P M
J Pathol. 1978 Jun;125(2):107-13. doi: 10.1002/path.1711250207.
Epithelioid cell granulomas were induced in rabbits previously sensitised with human sensory peripheral nerve extract by skin testing with homogenate of sural nerve. Ultrastructurally some of the cells contained in their cytoplasm abundant and dilated rough endoplasmic reticulum filled with a moderately dense product while the cytoplasm of other cells contained numerous membrane-bound vesicles. These cells show all the ultrastructural characteristics of epithelioid cells found in human granulomatous disease and in human states of granulomatous hypersensitivity. Thus we have developed an animal model which supports the concept of granulomatous hypersensitivity as a distinct entity in humans to be differentiated from foreign body and delayed-type hypersensitivity reactions. The model may also prove important in elucidating the pathogenesis of granuloma formation in non-lepromatous leprosy and other granulomatous disease and in defining the nature of the products of epithelioid cells.
通过用腓肠神经匀浆进行皮肤试验，在先前用人感觉外周神经提取物致敏的兔子中诱导出上皮样细胞肉芽肿。超微结构上，一些细胞的细胞质中含有丰富且扩张的粗面内质网，充满中等密度的产物，而其他细胞的细胞质中则含有大量膜结合囊泡。这些细胞表现出在人类肉芽肿性疾病和肉芽肿性超敏反应状态中发现的上皮样细胞的所有超微结构特征。因此，我们建立了一种动物模型，该模型支持肉芽肿性超敏反应作为人类一种独特实体的概念，可与异物和迟发型超敏反应区分开来。该模型在阐明非瘤型麻风及其他肉芽肿性疾病中肉芽肿形成的发病机制以及确定上皮样细胞产物的性质方面可能也具有重要意义。
