Little R A, Savic J, Stoner H B
J Pathol. 1978 Aug;125(4):201-4. doi: 10.1002/path.1711250405.
The effects of the H2-antagonists, metiamide and cimetidine, on the oedema following limb ischaemia or scald have been investigated in two strains of rat. No inhibition of oedema formation was found except when large doses of cimetidine were given before scalding. This effect was attributed to the fall in body temperature. Our results do not support the view that H2-receptors are concerned in the vascular response to injury.
在两种品系的大鼠中研究了H2拮抗剂甲硫米特和西咪替丁对肢体缺血或烫伤后水肿的影响。除了在烫伤前给予大剂量西咪替丁外，未发现对水肿形成有抑制作用。这种作用归因于体温下降。我们的结果不支持H2受体参与血管对损伤反应的观点。
