Paré P, Miller D
Am Rev Respir Dis. 1980 Apr;121(4):749-52. doi: 10.1164/arrd.1980.121.4.749.
Theoretically, histamine H2 antagonists could aggravate allergic bronchoconstriction (1) by increasing mediator release, and (2) by blocking histamine-induced bronchodilatation. We measured dynamic compliance, subdivisions of lung volume, and mortality in immunized guinea pigs after parenteral administration of antigen, with and without pretreatment with the H2-blocking agents cimetidine and metiamide. Administration of antigen caused significant mortality as well as decreases in dynamic compliance, total lung capacity, and vital capacity and increases in functional residual capacity. The prior administration of cimetidine or metiamide did not protect against or enhance these effects of antigen challenge.
理论上，组胺H2拮抗剂可能通过以下方式加重过敏性支气管收缩：（1）增加介质释放；（2）阻断组胺诱导的支气管扩张。我们测定了免疫豚鼠经静脉注射抗原后，在给予和不给予H2阻滞剂西咪替丁和甲硫米特预处理的情况下，其动态顺应性、肺容积细分及死亡率。注射抗原会导致显著的死亡率，以及动态顺应性、肺总量和肺活量降低，功能残气量增加。预先给予西咪替丁或甲硫米特并不能预防或增强抗原激发的这些效应。
