Tutton P J, Barkla D H
Anticancer Res. 1983 Jan-Feb;3(1):7-10.
Three histamine H2-receptor antagonists, Cimetidine, Metiamide and Ranitidine, were tested for their inhibitory effect on two experimental bowel cancer models. In the first model mitotic rates were measured in dimethylhydrazine-induced tumors of rat colon and in the second model volumetric changes in human large bowel cancer xenografts were assessed. In tumors of rat colon all three drugs were able to suppress mitotic activity, but the effects of Metiamide and Ranitidine were more prolonged than that of Cimetidine in each of two lines of human bowel cancer that were used. Metiamide and Ranitidine were also more effective growth inhibitors than was Cimetidine.
对三种组胺H2受体拮抗剂西咪替丁、甲硫米特和雷尼替丁在两种实验性肠癌模型中的抑制作用进行了测试。在第一个模型中，测量了二甲基肼诱导的大鼠结肠肿瘤中的有丝分裂率；在第二个模型中，评估了人结肠癌异种移植瘤的体积变化。在大鼠结肠肿瘤中，所有这三种药物均能够抑制有丝分裂活性，但在使用的两株人肠癌中，甲硫米特和雷尼替丁的作用比西咪替丁更持久。甲硫米特和雷尼替丁也是比西咪替丁更有效的生长抑制剂。
