Peckham G J, Fox W W
J Pediatr. 1978 Dec;93(6):1005-10. doi: 10.1016/s0022-3476(78)81239-6.
Indwelling pulmonary artery catheters were used for continuous monitoring of pulmonary artery pressure in ten infants with severe persistent pulmonary hypertention of the newborn. The labile nature of pulmonary artery pressure, with changes up to 50 mm Hg, was documented. Pulmonary artery pressure in the eight infants with suprasystemic pulmonary hypertension was analyzed at the time of maximum decrease in pressure (mean 36.1 mm Hg) and physiologic measurements were compared over an eight-hour period. During the study period when the infants were hyperventilated, as the Paco2 decreased from 48.9 to 28.3 mm Hg (P less than 0.02) the mean pulmonary artery pressure decreased by 36 mm Hg (P less than 0.001) to subsystemic pressure levels, and the mean AadeltaO2 decreased by 146 mm Hg (P less than 0.001). After the decrease in pulmonary artery pressure, patients were mechanically ventilated to maintain Paco2 in the range of 25 to 30 mm Hg until pulmonary hypertension gradually resolved in the six survivors.
对10例患有严重新生儿持续性肺动脉高压的婴儿使用肺动脉留置导管连续监测肺动脉压。记录到肺动脉压不稳定，变化幅度可达50毫米汞柱。在压力最大降幅时（平均36.1毫米汞柱）分析了8例患有系统性肺动脉高压婴儿的肺动脉压，并在8小时内比较了生理测量值。在研究期间，当婴儿进行过度通气时，随着动脉血二氧化碳分压从48.9毫米汞柱降至28.3毫米汞柱（P<0.02），平均肺动脉压下降36毫米汞柱（P<0.001）至低于系统性压力水平，平均肺泡 - 动脉血氧分压差下降146毫米汞柱（P<0.001）。在肺动脉压下降后，对患者进行机械通气以维持动脉血二氧化碳分压在25至30毫米汞柱范围内，直到6名存活者的肺动脉高压逐渐消退。
