Corrier D E, Wagner G G, Adams L G
Am J Vet Res. 1981 Jan;42(1):19-21.
Eight doses of cyclophosphamide (5 mg/kg), at 2-day intervals between doses, were administered IV to Anaplasma-carrier splenectomized calves. Significant decreases in serum immunoglobulins, diminished complement-fixing antibody response, and transitory leukopenia were associated with the treatment. Recrudescence of clinical Anaplasma infection occurred after the 5th dose of cyclophosphate was given and was characterized by rapid increase in parasitemia, marked decrease in PCV, and mortality. The results of the present study indicated that humoral mediated immunity may contribute to the maintenance of a state of equilibrium in the host-parasite relationship and that suppression of humoral immune responses may alter the course and outcome of infection in Anaplasma carriers.
对感染无形体的脾切除小牛静脉注射八剂环磷酰胺（5毫克/千克），剂量间隔为两天。治疗导致血清免疫球蛋白显著降低、补体结合抗体反应减弱以及短暂性白细胞减少。在给予第五剂环磷酰胺后，临床无形体感染复发，其特征为寄生虫血症迅速增加、红细胞压积显著降低以及死亡率上升。本研究结果表明，体液介导的免疫可能有助于维持宿主-寄生虫关系的平衡状态，并且抑制体液免疫反应可能会改变无形体携带者感染的进程和结果。
