Kuttler K L, Adams L G
Am J Vet Res. 1977 Sep;38(9):1327-30.
Dexamethasone was administered at the dose rate of 0.2 mg/kg of body weight to 11 splenectomized Anaplasma-carrier calves (groups 1 and 3) on Monday, Wednesday, and Friday for 3 weeks. Observations were made on these calves and on 7 nontreated, comparable calves (group 2) to determine the influence of treatment on carrier infections. Dexamethasone treatment was associated in every instance with an exacerbation of the Anaplasma parasitemia and a decrease in packed red cell volume. The episode of acute anaplasmosis was of short duration, resembling the primary response, except that complement-fixation response did not increase accordingly. Serum protein electrophoresis of serums from 4 calves (group 3) undergoing the drug-induced response failed to show any significant change during the 3-week treatment period, but did show a significant increase in gamma-globulin immediately after treatment.
对11头脾切除的无形体携带小牛（第1组和第3组），于周一、周三和周五按0.2毫克/千克体重的剂量率给予地塞米松，持续3周。对这些小牛以及7头未经治疗的对照小牛（第2组）进行观察，以确定治疗对携带感染的影响。在每种情况下，地塞米松治疗都与无形体寄生虫血症的加重以及红细胞压积的降低有关。急性无形体病发作持续时间较短，类似于初次反应，只是补体结合反应未相应增加。4头经历药物诱导反应的小牛（第3组）的血清蛋白电泳显示，在3周治疗期间未出现任何显著变化，但治疗后γ球蛋白立即显著增加。
