Kaidbey K H, Kligman A M
Arch Dermatol. 1981 May;117(5):258-63.
Coumarin and several of its derivatives were investigated for their photosensitizing properties. With a few exceptions, the coumarins are potentially strong photocontact sensitizers but do not evoke phototoxic reactions. Substitution at the 6 or 7 positions of the benzopyrone ring confers photoallergenic capability, whereas hydrogenation abolishes activity. Photo-cross-reactions among closely related derivatives can develop. The action spectrum for contact photodermatitis extends from 360 nm down to at least 300 nm. Data are presented to show that the photocontact allergic response is related to the ultraviolet A dose and to the concentration of the offending chemical.
对香豆素及其几种衍生物的光敏特性进行了研究。除少数例外情况，香豆素类是潜在的强效光接触致敏剂，但不会引发光毒性反应。苯并吡喃环的6位或7位发生取代会赋予光过敏能力，而氢化则会消除活性。密切相关的衍生物之间会发生光交叉反应。接触性光性皮炎的作用光谱从360纳米延伸至至少300纳米。所提供的数据表明，光接触过敏反应与紫外线A剂量以及引发问题的化学物质浓度有关。
