de Moragas J M, Prats G, Verger G
Arch Dermatol. 1981 May;117(5):292-4. doi: 10.1001/archderm.117.5.292.
A 40-year-old man had had a chronic, slowly spreading inflammatory process in the skin over the right knee of ten years' duration. Culture of a biopsy specimen grew Alternaria sp. Antimycotic susceptibility testing with flucytosine, amphotericin B, and miconazole nitrate was performed. The Alternaria was highly sensitive to the last two drugs. Miconazole nitrate, 1.2 g daily intravenously for 31 days, did not induce a clinical response. The lesions were then infiltrated with 10 mg of miconazole nitrate in 10 mL of polyethoxylated castor oil (Cremophor EL) twice weekly, with clearing of the lesions during a several-month period.
一名40岁男性，其右膝上方皮肤存在慢性、缓慢蔓延的炎症过程，持续了十年。活检标本培养出链格孢属真菌。对其进行了氟胞嘧啶、两性霉素B和硝酸咪康唑的抗真菌药敏试验。该链格孢属真菌对后两种药物高度敏感。每天静脉注射1.2克硝酸咪康唑，持续31天，未产生临床疗效。随后，每周两次将10毫克硝酸咪康唑加入10毫升聚乙氧基化蓖麻油（聚氧乙烯蓖麻油）中对病变部位进行浸润，数月内病变逐渐消退。
