Iwatsu T
Iwatsu Dermatological Clinic, Chiba, Japan.
Arch Dermatol. 1988 Dec;124(12):1822-5.
A 77-year-old woman had had a slowly spreading lesion of five years' duration on her left cheek. The lesion consisted of sharply demarcated, dark-red plaques with infiltration. A biopsy specimen from the lesion showed mixed-cell granulomatous infiltration in the upper to middle dermis. Hyphae were observed in the granulomatous tissue. Alternaria tenuissima was isolated from a biopsy specimen. Antimycotic susceptibility test with amphotericin B, ketoconazole, and flucytosine revealed that the isolate was sensitive to the former two drugs. The lesion was treated with intralesional infiltration of amphotericin B.
一名77岁女性左侧脸颊有一持续五年、缓慢扩散的皮损。该皮损由边界清晰的暗红色浸润性斑块组成。皮损活检标本显示真皮上部至中部有混合细胞肉芽肿性浸润。在肉芽肿组织中观察到菌丝。从活检标本中分离出细极链格孢。用两性霉素B、酮康唑和氟胞嘧啶进行抗真菌药敏试验，结果显示分离株对前两种药物敏感。皮损采用两性霉素B皮损内注射治疗。
