Moskovitz M, Bartlett J G
Arch Intern Med. 1981 Apr;141(5):663-4.
Fulminant and recurring pseudomembranous colitis developed in an elderly woman without prior antibiotic administration within the previous year. Stool culture yielded Clostridium difficile, and tissue cultures showed C difficile cytotoxin. Treatment with vancomycin hydrochloride was initially successful, but a serious relapse after its discontinuation necessitated low-dose long-term prophylaxis. Clostridium difficile may be responsible for pseudomembranous colitis unassociated with antibiotic therapy.
一名老年女性在过去一年未使用过抗生素的情况下发生了暴发性和复发性假膜性结肠炎。粪便培养检出艰难梭菌，组织培养显示艰难梭菌细胞毒素。最初使用盐酸万古霉素治疗取得成功，但停药后出现严重复发，需要进行低剂量长期预防。艰难梭菌可能是导致与抗生素治疗无关的假膜性结肠炎的原因。
