Salem H T, Seppälä M, Ranta T, Bohn H, Chard T
Br J Obstet Gynaecol. 1981 Apr;88(4):367-70. doi: 10.1111/j.1471-0528.1981.tb00998.x.
The levels of placental protein 5 (PP5) in pregnancy serum show an apparent increase after the addition of protamine sulphate. The difference of the apparent concentrations of serum PP5 in the presence and absence of protamine (delta PP5) was determined in 345 normal and abnormal pregnancies. A positive delta PP5 was less frequent in diabetic pregnancy (45 per cent) and pre-eclampsia (57 per cent) than in normal pregnancy (80 per cent). These findings provide further evidence that PP5 may be involved in the coagulation system, and in particular may relate to abnormal coagulation processes at the placental site.
妊娠血清中胎盘蛋白5（PP5）的水平在加入硫酸鱼精蛋白后明显升高。在345例正常和异常妊娠中测定了有无鱼精蛋白时血清PP5表观浓度的差异（ΔPP5）。糖尿病妊娠（45%）和先兆子痫（57%）中ΔPP5为阳性的情况比正常妊娠（80%）中少见。这些发现进一步证明PP5可能参与凝血系统，尤其可能与胎盘部位的异常凝血过程有关。
