腮腺鳞状细胞癌中糖胺聚糖的高合成水平。

A high level of glycosaminoglycan-synthesis of squamous cell carcinoma of the parotid gland.

作者信息

Takeuchi J, Sobue M, Sato E, Yoshida M, Uchibori N, Miura K

出版信息

Cancer. 1981 Apr 15;47(8):2030-5. doi: 10.1002/1097-0142(19810415)47:8<2030::aid-cncr2820470822>3.0.co;2-u.

DOI:10.1002/1097-0142(19810415)47:8<2030::aid-cncr2820470822>3.0.co;2-u

Abstract

Glycosaminoglycan content of a squamous cell carcinoma derived from the parotid gland was analyzed. The tumor tissue contained a large amount of glycosaminoglycans, and the amount was strikingly larger than found in other kinds of tumor tissues (pleomorphic adenoma, scirrhous carcinoma, myxoma, etc.) analyzed previously. A culture cell line established from this tumor showed a morphologic characteristic of differentiated squamous cell carcinoma, in vitro, forming many tonofilaments in the cytoplasma and numerous desmosomes in the intercellular connection. The carcinoma cell synthesized and secreted a large amount of glycosaminoglycans, consisting mainly of hyaluronic acid. The amount of 3H-labelled hyaluronic acid secreted by this carcinoma cell was about 20-fold larger than that by HeLa cell or KB cell. Conceivably, a high level of hyaluronic acid synthesis is one of the biologic characteristics of squamous cell carcinoma derived from the duct epithelium of the salivary gland.

摘要

对源自腮腺的鳞状细胞癌的糖胺聚糖含量进行了分析。肿瘤组织含有大量糖胺聚糖，其含量明显高于先前分析的其他类型肿瘤组织（多形性腺瘤、硬癌、黏液瘤等）。从该肿瘤建立的培养细胞系在体外表现出分化型鳞状细胞癌的形态特征，细胞质中形成许多张力丝，细胞间连接中有大量桥粒。癌细胞合成并分泌大量糖胺聚糖，主要由透明质酸组成。该癌细胞分泌的3H标记透明质酸量约为HeLa细胞或KB细胞的20倍。可以想象，高水平的透明质酸合成是源自唾液腺导管上皮的鳞状细胞癌的生物学特征之一。