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血浆睾酮葡萄糖醛酸苷:女性高雄激素血症(特发性多毛症和雄激素性脱发)的可靠指标。

Plasma testosterone glucosiduronate: a reliable indicator of female hyperandrogenism (idiopathic hirsutism and androgenic alopecia).

作者信息

Tamm J, Volkwein U, Tresguerres J A

出版信息

Clin Endocrinol (Oxf). 1980 Nov;13(5):431-5. doi: 10.1111/j.1365-2265.1980.tb03408.x.

DOI:10.1111/j.1365-2265.1980.tb03408.x
PMID:7226567
Abstract

Plasma concentrations of testosterone glucosiduronate (TG) have been determined by direct radioimmunoassay in seventeen normal females, twenty females with idiopathic hirsutism, and in twelve female subjects with androgenetic alopecia without hirsutism, respectively. The corresponding mean concentrations (+/- SD) of TG were 0.47 +/- 0.18; 1.42 +/- 0.55; 0.96 +/- 0.22 ng/ml. There was no overlapping of plasma TG levels of both groups with hyperandrogenism with those obtained in normal females. On the contrary, plasma concentrations of testosterone and dihydrotestosterone were found within the normal ranges in about 50% of the patients with hyperandrogenism. The synchronously estimated urinary excretion of TG revealed marked fluctuations (mean +/- SD): 27.0 +/- 12.0; 60.5 +/- 24.6; 36.3 +/- 14.1 microgram/24 h respectively.

摘要

分别采用直接放射免疫分析法测定了17名正常女性、20名特发性多毛症女性以及12名无多毛症的雄激素性脱发女性受试者血浆中睾酮葡萄糖醛酸苷(TG)的浓度。TG的相应平均浓度(±标准差)分别为0.47±0.18;1.42±0.55;0.96±0.22纳克/毫升。两组雄激素过多患者的血浆TG水平与正常女性的血浆TG水平均无重叠。相反,约50%雄激素过多患者的血浆睾酮和双氢睾酮浓度在正常范围内。同步估计的TG尿排泄量显示出明显波动(平均±标准差):分别为27.0±12.0;60.5±24.6;36.3±14.1微克/24小时。

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