Ohe K, Sumii K, Sano K, Kishimoto S, Miyoshi A
Endocrinol Jpn. 1980 Dec;27 Suppl 1:167-72. doi: 10.1507/endocrj1954.27.supplement_167.
In order to investigate the possible involvement of gastrointestinal hormones in functional disorders of the digestive tract, serum motilin, neurotensin and gastrin levels in their response to oral intake of fat and glucose were examined in patients with irritable colon syndrome and dumping syndrome. The following results were obtained. (1) Basal serum motilin levels were higher in patients with irritable colon syndrome than in normal subjects, and remained high after ingestion of either 50 g of butter or 50 g of glucose. (2) No consistent response in serum neurotensin levels was found in patients with irritable colon syndrome or in normal subjects. (3) An immediate increase in serum gastrin levels was found in response to fat ingestion both in patients with irritable colon syndrome and in normal subjects, but there was no difference between these two groups. (4) In a patient with typical dumping syndrome, a markedly high level of fasting serum motilin was found, and the level increased further after the oral intake of glucose. These findings suggest that motilin may be involved in the irritable colon syndrome and dumping syndrome.
为了研究胃肠激素在消化道功能紊乱中可能的作用，我们检测了肠易激综合征和倾倒综合征患者血清胃动素、神经降压素和胃泌素水平对口服脂肪和葡萄糖的反应。结果如下：（1）肠易激综合征患者的基础血清胃动素水平高于正常受试者，摄入50克黄油或50克葡萄糖后仍保持较高水平。（2）肠易激综合征患者和正常受试者的血清神经降压素水平均未发现一致的反应。（3）肠易激综合征患者和正常受试者摄入脂肪后血清胃泌素水平均立即升高，但两组之间无差异。（4）在一名典型的倾倒综合征患者中，空腹血清胃动素水平明显升高，口服葡萄糖后水平进一步升高。这些发现提示胃动素可能与肠易激综合征和倾倒综合征有关。
