Besterman H S, Mallinson C N, Modigliani R, Christofides N D, Pera A, Ponti V, Sarson D L, Bloom S R
Scand J Gastroenterol. 1983 Oct;18(7):845-52. doi: 10.3109/00365528309182104.
We have studied fasting levels and the response to a standard test breakfast of blood glucose and several gut hormones in 24 patients with ulcerative colitis, in 14 patients with Crohn's disease, and in 14 healthy control subjects. Patients with ulcerative colitis had significantly elevated fasting human pancreatic polypeptide (HPP) concentrations, and both basal and postprandial levels of gastrin, gastric inhibitory polypeptide (GIP), and motilin were greater than normal. In contrast, patients with Crohn's disease had normal gastrin levels but had increased fasting and postprandial levels of GIP and motilin and, in addition, of enteroglucagon, compared with controls. These patients also had greater than normal HPP concentrations 30 min after the breakfast. Normal levels of insulin, pancreatic glucagon, neurotensin, and vasoactive intestinal polypeptide were found in both groups of patients. Much remains to be known about the pathophysiology of these two debilitating diseases, and the abnormal release of gut hormones may be of importance.
我们研究了24例溃疡性结肠炎患者、14例克罗恩病患者及14名健康对照者的空腹血糖水平以及对标准试验早餐的血糖和几种胃肠激素反应。溃疡性结肠炎患者的空腹人胰多肽（HPP）浓度显著升高，胃泌素、胃抑肽（GIP）和胃动素的基础水平及餐后水平均高于正常。相比之下，克罗恩病患者的胃泌素水平正常，但与对照组相比，其空腹及餐后GIP、胃动素水平升高，此外，肠高血糖素水平也升高。这些患者在早餐后30分钟时的HPP浓度也高于正常。两组患者的胰岛素、胰高血糖素、神经降压素和血管活性肠肽水平均正常。关于这两种使人衰弱的疾病的病理生理学，仍有许多未知之处，胃肠激素的异常释放可能具有重要意义。
