Schlierf G, Schellenberg B, Stiehl A, Czygan P, Oster P
Digestion. 1981;21(1):44-9. doi: 10.1159/000198519.
The effects of fasting or a 600-cal diet on biliary lipid composition were studied in 20 persons with overweight. With complete fasting for 20 days and a mean weight loss of 650 g/day, biliary cholesterol fell significantly from 10.1 to 6.9 mol% and the 'lithogenic index' from 1.0 to 0.7. Following fasting, the index, in 10 of the 11 patients, was in the normal range below 1.0. With a 600-cal diet, in agreement with findings by other authors, there was no significant change of individual bile lipids or of the lithogenic index. While it has been shown that lithogenicity increases up to 16 h of fasting, it obviously significantly decreases with continued fasting. Fasting, therefore, in addition to manipulation of dietary cholesterol and, possibly, fiber consumption, appears to be an effective method for rapid lowering of biliary cholesterol saturation.
对20名超重者研究了禁食或600卡路里饮食对胆汁脂质成分的影响。在完全禁食20天且平均体重每天减轻650克的情况下，胆汁胆固醇从10.1摩尔%显著降至6.9摩尔%，“致石指数”从1.0降至0.7。禁食后，11名患者中有10名的该指数处于低于1.0的正常范围内。采用600卡路里饮食时，与其他作者的研究结果一致，个体胆汁脂质或致石指数均无显著变化。虽然已有研究表明禁食长达16小时会增加致石性，但持续禁食显然会使其显著降低。因此，禁食除了可控制膳食胆固醇以及可能控制纤维摄入量外，似乎还是一种快速降低胆汁胆固醇饱和度的有效方法。
