Hentschel E, Schuetze K, Dufek W
Hepatogastroenterology. 1984 Dec;31(6):266-8.
The incidence of duodenal ulcer relapse after initial therapy with concentrated aluminium-magnesium hydroxide (Maalox 70) or cimetidine (Tagamet) was investigated in a one-year follow-up study. 92.3% (24 out of 26) of the antacid patients and 76.2% (16 out of 21) of the cimetidine patients relapsed. The difference is not statistically significant. With respect to the pattern of onset of relapses, no difference was seen between the two groups. 33% of the recurrent lesions following treatment with antacids and 25% of those following cimetidine therapy were asymptomatic. This difference too is not significant. The results permit the conclusion that the mode of pharmaceutical therapy of ulcers (buffering of gastric acid by way of an antacid or inhibition of acid secretion by an H2-blocker) has no bearing on the further course of the ulcer disease.
在一项为期一年的随访研究中，对使用浓缩氢氧化铝镁（氢氧化铝镁70）或西咪替丁（泰胃美）进行初始治疗后十二指肠溃疡复发率进行了调查。使用抗酸剂的患者中有92.3%（26例中的24例）复发，使用西咪替丁的患者中有76.2%（21例中的16例）复发。差异无统计学意义。关于复发的起始模式，两组之间未见差异。抗酸剂治疗后复发性病变的33%和西咪替丁治疗后复发性病变的25%无症状。这一差异也不显著。结果表明，溃疡的药物治疗方式（通过抗酸剂缓冲胃酸或通过H2阻滞剂抑制胃酸分泌）与溃疡疾病的后续病程无关。
