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Streptozotocin-induced genotoxic effects in Chinese hamster cells: the resistant phenotype of V79 cells.

作者信息

Capucci M S, Hoffmann M E, Natarajan A T

机构信息

MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Sylvius Laboratories, The Netherlands.

出版信息

Mutat Res. 1995 Jul;347(2):79-85. doi: 10.1016/0165-7992(95)90074-8.

DOI:10.1016/0165-7992(95)90074-8
PMID:7651468
Abstract

The genotoxic effects of the methylating agent streptozotocin (STZ) on Chinese hamster cells CHO-9 and V79 were evaluated. The induction of cell killing, chromosomal aberrations, sister-chromatid exchanges (SCEs) and mutations was analyzed. Comparisons were made with the the STZ aglyconic analogue N-methyl-N-nitrosourea (MNU). V79 cells were found to be more resistant than CHO-9 cells to STZ and MNU killing effects, as well as to the induction of chromosomal aberrations and SCEs; however, V79 and CHO-9 cells appeared to be equally sensitive to the induction of 6-thioguanine resistant mutants by STZ. These results suggest that an error-free mechanism that tolerates DNA methylation damage confers a resistant phenotype to V79 cells to the genotoxic effects of methylation damage.

摘要

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