Enterline P E, Marsh G M
IARC Sci Publ. 1980(30):965-72.
A cohort, consisting of 7049 males who worked for one year or more as production or maintenance workers during the period 1945-1963 in one of eight US plants producing man-made mineral fibres, was followed for deaths through 1973. Standardized mortality ratios were elevated for major causes of death for men with 20 years or more since first exposure and were high when compared with those of men with less than 20 years since first exposure. None of the excesses was statistically significant. Since many causes of death were involved, the excesses observed are probably unrelated to exposure to man-made mineral fibres. Data for the three mineral wool plants included in the study could not be interpreted due to the possible use of asbestos in one or more of these plants. For the five fibrous glass plants, there was no evidence of an excess in malignant or nonmalignant respiratory disease related to exposure to respirable fibrous glass. Estimated historical respirable fibre concentrations to which workers from fibrous-glass plants were exposed were very low, less than 1/100th of the standard proposed by the US National Institute for Occupational Safety and Health.
一个队列由7049名男性组成，他们于1945年至1963年期间在美国八家生产人造矿物纤维的工厂中担任生产或维修工人一年或更长时间，并一直跟踪到1973年的死亡情况。首次接触后20年或更长时间的男性主要死因的标准化死亡比有所升高，与首次接触后不到20年的男性相比偏高。但所有这些超额情况在统计学上均无显著意义。由于涉及多种死因，观察到的超额情况可能与接触人造矿物纤维无关。由于研究中纳入的三家矿棉厂中可能使用了石棉，因此无法对这些工厂的数据进行解读。对于五家玻璃纤维厂，没有证据表明与接触可吸入玻璃纤维有关的恶性或非恶性呼吸道疾病有超额情况。玻璃纤维厂工人接触的估计历史可吸入纤维浓度非常低，不到美国国家职业安全与健康研究所提议标准的1/100。
