补体在病毒感染中的作用：末端补体成分（C5至C9）参与小鼠从辛德毕斯病毒感染中恢复。
Role of complement in viral infections: participation of terminal complement components (C5 to C9) in recovery of mice from Sindbis virus infection.
作者信息
Hirsch R L, Griffin D E, Winkelstein J A
出版信息
Infect Immun. 1980 Dec;30(3):899-901. doi: 10.1128/iai.30.3.899-901.1980.
Abstract
the pathogenesis of Sindbis virus infection was studied in congenic mice with normal levels of the fifth component of complement (C5) and in mice deficient in C5. Mice deficient in C5 had a higher mortality rate than mice with normal levels of C5 as well as impaired clearance of virus from their brain and feet.
摘要
在具有正常补体第五成分（C5）水平的同基因小鼠和缺乏C5的小鼠中研究了辛德毕斯病毒感染的发病机制。缺乏C5的小鼠比具有正常C5水平的小鼠死亡率更高，并且其从大脑和足部清除病毒的能力受损。
相似文献
1
Role of complement in viral infections: participation of terminal complement components (C5 to C9) in recovery of mice from Sindbis virus infection.
Infect Immun. 1980 Dec;30(3):899-901. doi: 10.1128/iai.30.3.899-901.1980.
2
Role of the immune response in age-dependent resistance of mice to encephalitis due to Sindbis virus.
J Infect Dis. 1976 Apr;133(4):456-64. doi: 10.1093/infdis/133.4.456.
3
The role of complement in viral infections. II. the clearance of Sindbis virus from the bloodstream and central nervous system of mice depleted of complement.
J Infect Dis. 1980 Feb;141(2):212-7. doi: 10.1093/infdis/141.2.212.
4
The effect of complement depletion on the course of Sindbis virus infection in mice.
J Immunol. 1978 Oct;121(4):1276-8.
5
C3-independent immune haemolysis: haemolysis of EAC14oxy2 cells by C5-C9 without participation of C3.
Immunology. 1984 Nov;53(3):575-82.
6
Age-dependent resistance to viral encephalitis: studies of infections due to Sindbis virus in mice.
J Infect Dis. 1972 Mar;125(3):257-62. doi: 10.1093/infdis/125.3.257.
7
Human alveolar macrophages synthesize the functional alternative pathway of complement and active C5 and C9 in vitro.
Scand J Immunol. 1986 Nov;24(5):603-8. doi: 10.1111/j.1365-3083.1986.tb02176.x.
8
Natural killer cells appear to play no role in the recovery of mice from Sindbis virus infection.
Immunology. 1981 May;43(1):81-9.
9
C9 hemolytic activity of the soluble C5b-9 complex of guinea pig complement, analogous to human SC5b-9.
J Immunol. 1979 Nov;123(5):1989-95.
引用本文的文献
1
In the Crosshairs: RNA Viruses OR Complement?
Front Immunol. 2020 Sep 29;11:573583. doi: 10.3389/fimmu.2020.573583. eCollection 2020.
2
Immunopathogenesis of alphaviruses.
Adv Virus Res. 2020;107:315-382. doi: 10.1016/bs.aivir.2020.06.002. Epub 2020 Jul 8.
3
Complement Evasion Strategies of Viruses: An Overview.
Front Microbiol. 2017 Jun 16;8:1117. doi: 10.3389/fmicb.2017.01117. eCollection 2017.
4
Complement modulates pathogenesis and antibody-dependent neutralization of West Nile virus infection through a C5-independent mechanism.
Virology. 2009 Oct 10;393(1):11-5. doi: 10.1016/j.virol.2009.08.019. Epub 2009 Sep 9.
5
Complement and its role in protection and pathogenesis of flavivirus infections.
Vaccine. 2008 Dec 30;26 Suppl 8:I100-7. doi: 10.1016/j.vaccine.2008.11.061.
6
Vaccinia virus extracellular enveloped virion neutralization in vitro and protection in vivo depend on complement.
J Virol. 2009 Feb;83(3):1201-15. doi: 10.1128/JVI.01797-08. Epub 2008 Nov 19.
7
West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H.
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19111-6. doi: 10.1073/pnas.0605668103. Epub 2006 Nov 28.
8
Protective immune responses against West Nile virus are primed by distinct complement activation pathways.
J Exp Med. 2006 May 15;203(5):1371-81. doi: 10.1084/jem.20052388. Epub 2006 May 1.
9
Complement activation is required for induction of a protective antibody response against West Nile virus infection.
J Virol. 2005 Jun;79(12):7466-77. doi: 10.1128/JVI.79.12.7466-7477.2005.
10
The alphaviruses: gene expression, replication, and evolution.
Microbiol Rev. 1994 Sep;58(3):491-562. doi: 10.1128/mr.58.3.491-562.1994.
本文引用的文献
1
The role of complement in viral infections. II. the clearance of Sindbis virus from the bloodstream and central nervous system of mice depleted of complement.
J Infect Dis. 1980 Feb;141(2):212-7. doi: 10.1093/infdis/141.2.212.
2
Role of the immune response in age-dependent resistance of mice to encephalitis due to Sindbis virus.
J Infect Dis. 1976 Apr;133(4):456-64. doi: 10.1093/infdis/133.4.456.
3
4
The effect of complement depletion on the course of Sindbis virus infection in mice.
J Immunol. 1978 Oct;121(4):1276-8.
Zotero 插件