Baumgärtner W K, Metzler A E, Krakowka S, Koestner A
Infect Immun. 1981 Mar;31(3):1177-83. doi: 10.1128/iai.31.3.1177-1183.1981.
A virus, 78-238, isolated from the cerebrospinal fluid of a dog with neurological dysfunction, was characterized as a paramyxovirus. This conclusion was supported by viral cytopathic effects and morphological appearance of virions and nucleocapsids in infected cells. Nucleocapsids were found in the cytoplasm of all infected cells and in the nuclei of 0.001% of these cells. Growth curves revealed that a high percentage (>/=76%) of infectious progeny virus was cell released. Persistent infection of Vero cells with 78-238 showed a consistently high percentage of fluorescence-positive cells and a low proportion of hemadsorption-positive cells. Serological studies indicate that the virus was closely related to Simian virus 5 and reference canine parainfluenza virus.
从一只患有神经功能障碍的狗的脑脊液中分离出的病毒78 - 238被鉴定为副粘病毒。这一结论得到了病毒细胞病变效应以及感染细胞中病毒粒子和核衣壳的形态学表现的支持。在所有感染细胞的细胞质中以及0.001%的这些细胞的细胞核中发现了核衣壳。生长曲线显示，高比例（≥76%）的感染性子代病毒是细胞释放型的。用病毒78 - 238持续感染非洲绿猴肾细胞显示，荧光阳性细胞的比例始终很高，而血细胞吸附阳性细胞的比例较低。血清学研究表明，该病毒与猴病毒5和参考犬副流感病毒密切相关。
