Schaad U B, McCracken G H
Helv Paediatr Acta. 1981 Feb;36(1):19-30.
Although effective antimicrobial agents are available and despite considerable advances in rapid diagnosis and supportive care, the prognosis of neonatal bacterial meningitis remains relatively poor. A pharmacological concept for antimicrobial therapy of neonatal meningitis is presented which is derived from the pertinent in vitro and in vivo data concerning the currently employed and investigational regimens. Specific recommendations for antimicrobial management of neonatal meningitis are given based on attainment of appreciable bactericidal activity in CSF which should result in prompt eradication of the offending pathogen from CSF.
尽管有有效的抗菌药物，且在快速诊断和支持治疗方面取得了显著进展，但新生儿细菌性脑膜炎的预后仍然相对较差。本文提出了一种新生儿脑膜炎抗菌治疗的药理学概念，该概念源自有关当前使用的和正在研究的治疗方案的相关体外和体内数据。基于在脑脊液中获得可观的杀菌活性，给出了新生儿脑膜炎抗菌管理的具体建议，这应能迅速从脑脊液中根除致病病原体。
