Hall W G, Bryan T E
J Comp Physiol Psychol. 1981 Apr;95(2):240-51. doi: 10.1037/h0077771.
Infusions of sucrose or quinine were delivered through cannulas implanted in rat pup's mouths. Intake was measured, and behavioral responses were scored. Responsiveness to sweet and bitter tastes emerged over the first 2 wk of postnatal life. Pups showed discrimination between water and sucrose in their mouthing behavior and general activity from 3 days of age, but in their intake only from 6 days of age. Discrimination between water and quinine was not shown until 9 days of age in either behavior or intake. Even then, the stereotypic aversion reactions (paw treading, chin scraping) that characterize the adult response to quinine were not apparent until 12 days. By 15 days of age, preferences for sucrose and aversions to quinine were robust. They resembled those of adult rats and did not depend on previous experience with either solution.
通过植入幼鼠口腔的套管输送蔗糖或奎宁溶液。测量摄入量，并对行为反应进行评分。对甜味和苦味的反应在出生后的前两周出现。幼崽在3日龄时，在舔舐行为和一般活动中就能区分水和蔗糖，但在摄入量方面直到6日龄才有区分。水和奎宁的区分在行为或摄入量上直到9日龄才出现。即便如此，成年大鼠对奎宁典型的刻板厌恶反应（用爪子踩、刮下巴）直到12日龄才明显。到15日龄时，对蔗糖的偏好和对奎宁的厌恶已经很强烈。它们类似于成年大鼠的反应，且不依赖于之前对任何一种溶液的体验。
