Merritt T A, Stuard I D, Puccia J, Wood B, Edwards D K, Finkelstein J, Shapiro D L
J Pediatr. 1981 Jun;98(6):949-56. doi: 10.1016/s0022-3476(81)80603-8.
Cytopathologic examinations of tracheobronchial aspirates from 108 infants sampled during mechanical ventilation demonstrated a well-defined progression of cytologic changes in bronchial cells that could be divided into three classes. Seventy percent of infants with respiratory distress syndrome who developed bronchopulmonary dysplasia had pulmonary effluent cytology designated Class III; no infants with RDS but without BPD had these cytologic findings. Additionally, a temporal progression of events involving polymorphonuclear leukocyte and macrophage populations occurred in the absence of infection; these events were associated with duration of assisted ventilation and oxygen exposure. The technique described provides a useful way to monitor the progression of lung injury and repair and offers a cytologic method to predict and diagnose the development of bronchopulmonary dysplasia.
对108例机械通气期间采样的婴儿气管支气管吸出物进行的细胞病理学检查显示，支气管细胞的细胞学变化有明确的进展过程，可分为三类。发生支气管肺发育不良的呼吸窘迫综合征婴儿中，70%的肺流出物细胞学为III类；而患有呼吸窘迫综合征但未发生支气管肺发育不良的婴儿无这些细胞学表现。此外，在没有感染的情况下，多形核白细胞和巨噬细胞群体出现了时间上的变化过程；这些变化与辅助通气时间和吸氧时间有关。所描述的技术为监测肺损伤和修复的进展提供了一种有用的方法，并提供了一种细胞学方法来预测和诊断支气管肺发育不良的发生。
