Merritt T A, Puccia J M, Stuard I D
Acta Cytol. 1981 Nov-Dec;25(6):631-9.
Tracheobronchial effluent from 108 infants with respiratory distress syndrome (RDS) was classified cytologically in relationship to the duration of endotracheal intubation and mechanical ventilation with supplemental oxygen. Three cytologic classes emerged: class I (1 to 4 days), associated with exfoliation of cohesive and organized sheets of tracheobronchial cells, class II (4 to 10 days), during which regeneration of tracheobronchial cells was prominent and reactive cells were present, and class III (after 10 days), during which squamous metaplasia, chronic inflammation and regeneration were characteristic. An influx of polymorphonuclear neutrophilic leukocytes and macrophages was typical of classes II and III. In 70% of the cases, the identification of class III changes enabled the diagnosis of bronchopulmonary dysplasia (BPD) to be made earlier than by radiography alone. This classification of tracheobronchial cytology should be of benefit in the identification and treatment of infants with bronchopulmonary dysplasia. It may also offer a more direct means for evaluating new therapy to prevent or modify this disorder.
对108例患有呼吸窘迫综合征（RDS）的婴儿的气管支气管分泌物进行了细胞学分类，该分类与气管插管及使用补充氧气进行机械通气的持续时间相关。出现了三种细胞学类型：I类（1至4天），与气管支气管细胞的凝聚性和有组织的片状脱落相关；II类（4至10天），在此期间气管支气管细胞再生显著且存在反应性细胞；III类（10天之后），在此期间鳞状化生、慢性炎症和再生是其特征。多形核嗜中性白细胞和巨噬细胞的流入是II类和III类的典型表现。在70%的病例中，III类变化的识别使得支气管肺发育不良（BPD）的诊断比仅通过放射学检查能更早做出。这种气管支气管细胞学分类应有助于支气管肺发育不良婴儿的识别和治疗。它还可能为评估预防或改善这种疾病的新疗法提供更直接的手段。
