支气管肺发育不良婴儿气管吸出物中可溶性细胞间黏附分子-1增加。

Increased soluble ICAM-1 in tracheal aspirates of infants with bronchopulmonary dysplasia.

作者信息

Kojima T, Sasai M, Kobayashi Y

机构信息

Department of Paediatrics, Kansai Medical University, Osaka, Japan.

出版信息

Lancet. 1993 Oct 23;342(8878):1023-4. doi: 10.1016/0140-6736(93)92880-3.

DOI:10.1016/0140-6736(93)92880-3

PMID:8105265

Abstract

Raised concentrations of soluble intracellular adhesion molecule 1 (sICAM-1) in tracheal aspirates from premature infants may predict development of bronchopulmonary dysplasia (BPD). We measured sICAM-1 in tracheal aspirates and serum samples from 15 newborn babies (9 with BPD, 6 without BPD) at 2-4, 6-7, and 12-14 days of age. sICAM-1 concentrations in tracheal aspirates were significantly raised at 6-7 and 12-14 days of age in infants who later developed BPD compared with infants who did not develop BPD. Serum samples from the two groups did not differ significantly in sICAM-1. Raised sICAM-1 in tracheal aspirate was a good predictor of lung injury in infants who later developed BPD.

摘要

早产儿气管吸出物中可溶性细胞间黏附分子1（sICAM-1）浓度升高可能预示支气管肺发育不良（BPD）的发生。我们在15例新生儿（9例患BPD，6例未患BPD）2 - 4天、6 - 7天和12 - 14天时测量了其气管吸出物和血清样本中的sICAM-1。与未发生BPD的婴儿相比，后来发生BPD的婴儿在6 - 7天和12 - 14天时气管吸出物中的sICAM-1浓度显著升高。两组的血清样本在sICAM-1方面无显著差异。气管吸出物中sICAM-1升高是后来发生BPD的婴儿肺损伤的良好预测指标。