使用高能中子对血红蛋白进行辐照。
Irradiation of hemoglobin using high-energy neutrons.
作者信息
Oliver F W, Silversmith E F
出版信息
J Natl Med Assoc. 1981 May;73(5):433-6.
Aqueous solutions of oxyhemoglobin were irradiated with 80 Mev neutrons with doses of 0.9 Mrads and 1,400 rads. Spectrophotometric measurements were made on the irradiated solutions. Absorption measurements for the 0.9-Mrad irradiation indicated that oxyhemoglobin was converted into methemoglobin and that porphyrin molecules were destroyed. The 1,400-rad irradiation gave no measureable conversion of oxyhemoglobin into methemoglobin. There was, however, destruction of some of the oxyhemoglobin.Results indicated that high-energy neutron irradiation causes structural alteration of the hemoglobin molecule and that this alteration is similar to that found for gamma and x-rays.
用剂量为0.9兆拉德和1400拉德的80兆电子伏中子辐照氧合血红蛋白的水溶液。对辐照后的溶液进行分光光度测量。0.9兆拉德辐照的吸收测量表明，氧合血红蛋白转化为高铁血红蛋白，卟啉分子被破坏。1400拉德的辐照未使氧合血红蛋白转化为高铁血红蛋白，但有一些氧合血红蛋白被破坏。结果表明，高能中子辐照会导致血红蛋白分子的结构改变，这种改变与γ射线和X射线造成的改变相似。
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