Aoki K, Mochizuki A, Hotta K
Jpn Circ J. 1981 May;45(5):547-51. doi: 10.1253/jcj.45.547.
Development of tension in aortic helical strips was studied using the male Kyoto Wistar normotensive (KNR) and age-, sex-matched spontaneously hypertensive rats (SHR) (8 to 10 weeks) to clarify the contractile response of vascular smooth muscle in SHR. In Ca2+-containing solution, noradrenaline-induced tension was smaller in SHR than in KNR. After washing the strips with Ca2+-free EGTA solution, the tension that developed by the addition of Ca2+ was greater in SHR than in KNR. Tension induced by the combination of Ca2+ and noradrenaline was the same between the KNR and SHR. It is assumed that these differences between the KNR and SHR aortic strips may be attributed to the abnormal contractility of the vascular smooth muscle in SHR.
使用雄性京都Wistar正常血压大鼠（KNR）和年龄、性别匹配的自发性高血压大鼠（SHR）（8至10周龄）研究主动脉螺旋条带中张力的发展，以阐明SHR中血管平滑肌的收缩反应。在含钙离子的溶液中，去甲肾上腺素诱导的张力在SHR中比在KNR中小。用无钙离子的EGTA溶液冲洗条带后，添加钙离子所产生的张力在SHR中比在KNR中大。钙离子和去甲肾上腺素联合诱导的张力在KNR和SHR之间是相同的。据推测，KNR和SHR主动脉条带之间的这些差异可能归因于SHR中血管平滑肌的异常收缩性。
