Bell D M, Brink E W, Nitzkin J L, Hall C B, Wulff H, Berkowitz I D, Feorino P M, Holman R C, Huntley C L, Meade R H, Anderson L J, Cheeseman S H, Fiumara N J, Gilfillan R F, Keim D E, Modlin J F
N Engl J Med. 1981 Jun 25;304(26):1568-75. doi: 10.1056/NEJM198106253042603.
Investigation of two outbreaks of Kawasaki syndrome (KS) in the United States in 1979 and in 1980 revealed no evidence of person-to-person transmission or of a common-source exposure among patients. Questionnaire data showed that KS was more likely to occur in children of middle and upper socioeconomic status than in those of lower status (P less than 0.05 and P less than 0.001 for the respective outbreaks) and that patients with KS had a higher incidence of an antecedent, primarily respiratory illness than did controls matched for age, sex, and race (83% of patients in the first outbreak vs. 30% of one control group, P less than 0.01, and vs. 36% of another control group, P less than 0.02; and 56% of patients in the second outbreak vs. 32% of their controls, P less than 0.02). However, laboratory studies did not identify an etiologic agent for either KS or for the antecedent illness that may be a risk factor for KS.
1979年和1980年在美国对两起川崎病（KS）疫情的调查显示，没有证据表明患者之间存在人际传播或共同来源暴露。问卷调查数据显示，与社会经济地位较低的儿童相比，川崎病更有可能发生在社会经济地位中上层的儿童中（两次疫情分别为P<0.05和P<0.001），并且川崎病患者在发病前主要为呼吸道疾病的发病率高于年龄、性别和种族匹配的对照组（第一次疫情中83%的患者与一个对照组的30%相比，P<0.01，与另一个对照组的36%相比，P<0.02；第二次疫情中56%的患者与他们的对照组的32%相比，P<0.02）。然而，实验室研究未确定川崎病或可能是川崎病危险因素的前驱疾病的病原体。
