Dean A G, Melish M E, Hicks R, Palumbo N E
J Pediatr. 1982 Apr;100(4):552-7. doi: 10.1016/s0022-3476(82)80751-8.
A community-wide outbreaks of Kawasaki syndrome, apparently the first in the United States, occurred in Hawaii in the first half of 1978. Twenty-seven of the 33 cases were subjected to intensive epidemiologic and microbiologic study. Patients with Kawasaki syndrome, compared to the general population, more often had Japanese ancestry, high-income status, and possibly a history of respiratory infection in the preceding month (44%). Staphylococcus aureus was not found in high frequency in the patients (15%), and viral cultures and serologic studies, immune electron microscopy, and guinea pig and primate inoculation did not reveal a causative microorganism. Febrile illnesses in guinea pigs inoculated with a skin biopsy specimen should not be further passaged.
1978年上半年，美国夏威夷发生了显然是首例的全社区范围的川崎综合征疫情。33例病例中的27例接受了深入的流行病学和微生物学研究。与普通人群相比，川崎综合征患者更常具有日本血统、高收入地位，并且可能在前一个月有呼吸道感染史（44%）。患者中金黄色葡萄球菌的检出频率不高（15%），病毒培养、血清学研究、免疫电子显微镜检查以及豚鼠和灵长类动物接种均未发现致病微生物。接种皮肤活检标本的豚鼠发生的发热性疾病不应再传代。
