Leibovici J, Stark Y, Eldar T, Brudner G, Wolman M
Recent Results Cancer Res. 1980;75:173-9. doi: 10.1007/978-3-642-81491-4_27.
The mechanism of the antitumoral effect of levan was studied in the C57BL mice-Lewis lung carcinoma system. Modulation of host immune response and a direct inhibitory effect on tumor cells were found. Local treatment was more effective when begun early. It reduced tumor incidence without affecting the size of developing tumors. Systemic treatment was more effective when started late, inhibiting equally the tumor size in all mice. Macrophages are involved in local, lymphocytes possibly in systemic, inhibition. A direct effect on tumor cells was suggested by a decrease in oncogenicity, following preincubation with levan. Levan augments the antitumoral effect of cyclophosphamide in vivo and in vitro.
在C57BL小鼠-刘易斯肺癌系统中研究了左聚糖的抗肿瘤作用机制。发现它可调节宿主免疫反应并对肿瘤细胞有直接抑制作用。早期开始局部治疗更有效。它可降低肿瘤发生率，而不影响正在生长的肿瘤大小。晚期开始全身治疗更有效，可同等程度抑制所有小鼠的肿瘤大小。巨噬细胞参与局部抑制，淋巴细胞可能参与全身抑制。左聚糖预孵育后致癌性降低，提示其对肿瘤细胞有直接作用。左聚糖在体内和体外均可增强环磷酰胺的抗肿瘤作用。
