Poppius H
Respiration. 1980;40(5):278-83. doi: 10.1159/000194290.
In a cross-over experiment, 16 adult asthmatics slowly inhaled, at functional residual capacity, cumulative doses of terbutaline spray with and without extension of the mouthpiece of the aerosol canister by a cylindrical tube (length 10.0 cm, diameter 3.2 cm). No difference was found between the two modes of treatment with regard to the bronchodilator response assessed by measurement of specific airway conductance, registration of expiratory flow-volume curves and determination of helium response. The results suggest that the use of an extension tube may not promote a more extensive nor a more peripheral deposition in the bronchial tree of a properly inhaled pressurized aerosol drug.
在一项交叉实验中，16名成年哮喘患者在功能残气量时缓慢吸入累计剂量的特布他林喷雾剂，一种情况是不使用延长管，另一种情况是通过一个圆柱形管（长度10.0厘米，直径3.2厘米）延长气雾剂罐的吸嘴。通过测量比气道传导率、记录呼气流量-容积曲线以及测定氦反应来评估支气管扩张反应，结果发现两种治疗方式之间没有差异。结果表明，对于正确吸入的加压气雾剂药物，使用延长管可能不会促进其在支气管树中更广泛或更外周的沉积。
