Perel E, Davis S, Killinger D W
Steroids. 1981 Mar;37(3):345-52. doi: 10.1016/s0039-128x(81)90314-7.
Incubation studies have been carried out using normal breast tissue and breast tissue from patients with gynecomastia, mammary dysplasia and breast carcinoma to determine the pattern of androstenedione metabolism. All tissues formed estrone (E1) and testosterone (T) in all incubations. Estradiol (E2) was isolated in incubations of tissue from 1 of 6 patients with mammary dysplasia, 5 of 6 patients with gynecomastia and in all incubations with normal and carcinoma tissue. Estrone formation was lowest in mammary dysplasia and gynecomastia, and higher in apparently normal breast tissue. The greatest E1 formation was found in incubations with breast carcinoma tissue, although there was considerable variation within this tissue group. Estradiol formation was low in all tissues, with the highest conversion rates in carcinoma tissue. Testosterone formation in carcinoma tissue was greater than in mammary dysplasia or gynecomastia, but similar to apparently normal tissue. These results indicate that breast tissue from different pathological states varies in its capacity to aromatize androstenedione (A) to estrogenic products and to convert it to other androgens. They have also shown that the pattern of metabolism is distinctive for the nature of the pathological abnormality.
已使用正常乳腺组织以及来自男性乳房发育症、乳腺发育异常和乳腺癌患者的乳腺组织进行孵育研究，以确定雄烯二酮的代谢模式。在所有孵育过程中，所有组织均形成了雌酮（E1）和睾酮（T）。在6例乳腺发育异常患者中的1例、6例男性乳房发育症患者中的5例的组织孵育过程中以及在所有正常组织和癌组织的孵育过程中均分离出了雌二醇（E2）。雌酮的形成在乳腺发育异常和男性乳房发育症中最低，在明显正常的乳腺组织中较高。在乳腺癌组织的孵育过程中发现雌酮形成最多，尽管该组织组内存在相当大的差异。所有组织中雌二醇的形成均较低，癌组织中的转化率最高。癌组织中睾酮的形成大于乳腺发育异常或男性乳房发育症中的形成，但与明显正常的组织相似。这些结果表明，来自不同病理状态的乳腺组织将雄烯二酮（A）芳香化为雌激素产物并将其转化为其他雄激素的能力各不相同。他们还表明，代谢模式因病理异常的性质而异。
