长期培养的乳腺癌细胞不能将雄烯二酮芳香化。

Failure of breast cancer cells in long-term culture to aromatize androstenedione.

作者信息

D'Agata R, Monaco M E, Lippman M E, Loriaux D L

出版信息

Steroids. 1978 Apr;31(4):463-70. doi: 10.1016/0039-128x(78)90028-4.

Abstract

The ability of breast cancer cells in long-term tissue culture to aromatize androstenedione to estrone and estradiol was examined. (3H) androstenedione (1.1 x 10(-7)M) was incubated with 9 cell lines of human breast cancer and one line derived from a dimethylbenz(a)anthracene induced rat mammary tumor. No conversion to estrone or estradiol was detected. The findings are discussed in light of previous studies showing aromatization of androgens in breast cancer tissues.

摘要

研究了长期组织培养中的乳腺癌细胞将雄烯二酮芳香化转化为雌酮和雌二醇的能力。将（3H）雄烯二酮（1.1×10⁻⁷M）与9个人乳腺癌细胞系以及1个由二甲基苯并（a）蒽诱导的大鼠乳腺肿瘤细胞系一同孵育。未检测到向雌酮或雌二醇的转化。根据先前显示乳腺癌组织中雄激素芳香化的研究对这些发现进行了讨论。