Nara Y, Horie R, Yamori Y
Stroke. 1981 Sep-Oct;12(5):693-5. doi: 10.1161/01.str.12.5.693.
Glucose metabolites in the rat brain were measured under various stages of ischemia. In acute ischemia induced by bilateral carotid artery ligation, phosphocreatine and ATP levels were significantly decreased and lactate levels were significantly increased in stroke-prone spontaneously hypertensive rats (SHRSP). These extreme changes were not observed in normotensive Wistar-Kyoto rats (WKY) and stroke-resistant spontaneously hypertensive rats (SHRSR), under the same conditions. In chronic ischemia induced by long-lasting regional cerebral blood flow reduction due to severe hypertension, similar changes were observed only in SHRSP at the advanced stage. The levels of glucose metabolites in the brain were confirmed to be well maintained within control ranges even though the cerebral tissues were subjected to the chronic ischemia related to severe hypertension.
在不同缺血阶段对大鼠脑内的葡萄糖代谢物进行了测量。在双侧颈动脉结扎诱导的急性缺血中，易患中风的自发性高血压大鼠（SHRSP）的磷酸肌酸和ATP水平显著降低，乳酸水平显著升高。在相同条件下，正常血压的Wistar-Kyoto大鼠（WKY）和抗中风的自发性高血压大鼠（SHRSR）未观察到这些极端变化。在由于严重高血压导致长期局部脑血流减少所诱导的慢性缺血中，仅在晚期的SHRSP中观察到类似变化。尽管脑组织遭受了与严重高血压相关的慢性缺血，但脑内葡萄糖代谢物水平仍被证实能很好地维持在对照范围内。
