Jobo T, Kuramoto H, Morisawa T
Acta Obstet Gynaecol Jpn. 1981 May;33(5):651-8.
Microglandular hyperplasia which may not be familiar in this country is a polypoid lesion of the cervix and has been noticed as the lesion sustained by contraceptive pills. The retrospective study was performed to clarify whether or not this lesion have been enclosed into diagnosis of cervical polyp at routine clinic. 1. Among 895 cases of cervical polyp resected at our clinic during 7 years from 1971, 7 microglandular hyperplasias were found, showing 0.8% of the incidence. 2. Ages of the 7 patients ranged from 42 to 52 years, and the average was 45.7. Three cases complained of metrorrhagia. 3. One woman was taking oral contraceptives and the other was on hormonal therapy. No patient was pregnant. 4. Polyps with microglandular hyperplasia were usually above the size of small finger tip. In one case, a large papillary mass (3.0 x 3.5 cm) resembling to carcinoma of the cervix was experienced. 5. There were no characteristic findings in cytology except a case with enlarged and vesicular cells. 6. Histologically, the lesion consists of numerous microglandular spaces lined by regular cuboidal or flat cells without atypism. The eosinophilic cytoplasms are not vacuolated. Glands are not clearly demarcated from edematous stroma. This change may be mistaken for adenocarcinoma.
微腺型增生在我国可能并不常见，它是宫颈的一种息肉样病变，已被注意到是由避孕药引起的病变。进行这项回顾性研究是为了明确在常规临床诊断中这种病变是否被纳入宫颈息肉的诊断。1. 在1971年至1977年这7年间，我们诊所切除的895例宫颈息肉病例中，发现了7例微腺型增生，发病率为0.8%。2. 这7例患者的年龄在42岁至52岁之间，平均年龄为45.7岁。3例患者有月经过多的症状。3. 1名女性正在服用口服避孕药，另1名正在接受激素治疗。无患者怀孕。4. 伴有微腺型增生的息肉通常大于指尖大小。有1例出现了一个类似宫颈癌的大乳头状肿物（3.0×3.5厘米）。5. 除1例细胞增大且呈水泡状的病例外，细胞学检查无特征性发现。6. 组织学上，病变由许多微腺腔组成，内衬规则的立方状或扁平细胞，无异型性。嗜酸性细胞质无空泡。腺体与水肿的间质分界不清。这种改变可能会被误诊为腺癌。
