Przybylski J, Trzebski A, Przybyszewski A
Acta Physiol Pol. 1980 Sep-Oct;31(5):463-8.
Experiments were carried out on 6-7 months old spontaneously hypertensive rats (SHR) (NIbm) of the Okamoto-Aoki strain and age matched normotensive control rats (NCR) of the same age group. Acute hypoxia produced bradycardia and a fall of blood pressure in artificially ventilated NCR and a biphasic heart rate response (acceleration-deceleration) in SHR. After bilateral vagotomy or atropine administration a pressor response to hypoxia occurred in NCR and SHR. We conclude that adult SHR exhibit reduced sensitivity of the cardio-vagal component of the arterial chemoreflex.
实验在冈本-青木品系6至7月龄的自发性高血压大鼠（SHR）（NIbm）以及同年龄组年龄匹配的正常血压对照大鼠（NCR）身上进行。急性缺氧在人工通气的NCR中导致心动过缓和血压下降，而在SHR中引起双相心率反应（加速-减速）。双侧迷走神经切断或给予阿托品后，NCR和SHR对缺氧均出现升压反应。我们得出结论，成年SHR的动脉化学反射的心脏迷走神经成分敏感性降低。
