Miura S, Asakura H, Tsuchiya M
Angiology. 1981 May;32(5):345-54. doi: 10.1177/000331978103200508.
Histopathologic and lymphographic studies were performed in 4 patients with protein-losing gastropathy to elucidate the degree of lymphatic disorders and their contribution to clinical features. Histologic examination of gastric mucosa showed various degrees of hyperplasia of the surface epithelium and cystic dilatation of glands, which were considered to be characteristic findings of protein losing gastropathy. Moreover, in 3 of 4 patients there were edematous change of the lamina propria or the submucosa, and marked lymphangiectasia was seen in the submucosa of 3 patients and in the lamina propria of the other. Performed lymphograms showed an increase in the number of lymphatic vessels and lymph nodes in the iliopelvic and lumbar regions of 2 of the patients. This high incidence of lymphatic abnormalities in patients with protein-losing gastropathy suggested that such systemic lymphatic disorders were an important etiologic factor. However, such abnormalities in lymphatic system were not demonstrated in all cases of protein-losing gastropathy. Therefore, lymphatic disorders were not considered to be the primary cause of gastric protein loss, but the important factor that modifies the variety of lost protein and its clinical features.
对4例蛋白丢失性胃病患者进行了组织病理学和淋巴管造影研究，以阐明淋巴系统紊乱的程度及其对临床特征的影响。胃黏膜组织学检查显示表面上皮不同程度增生以及腺体囊性扩张，这些被认为是蛋白丢失性胃病的特征性表现。此外，4例患者中有3例固有层或黏膜下层出现水肿改变，3例患者的黏膜下层及另1例患者的固有层可见明显的淋巴管扩张。所进行的淋巴管造影显示，2例患者的髂盆腔和腰部区域淋巴管和淋巴结数量增加。蛋白丢失性胃病患者中淋巴系统异常的高发生率表明，这种全身性淋巴系统紊乱是一个重要的病因。然而，并非所有蛋白丢失性胃病病例都显示出淋巴系统的此类异常。因此，淋巴系统紊乱不被认为是胃蛋白丢失的主要原因，而是影响丢失蛋白种类及其临床特征的重要因素。
